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Exclusion criteria in studies typically include Wilson's disease, copper allergy, and pregnancy due to insufficient data in those populations

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Interestingly, it was previously proposed that the ability of KEAP1 to sense H 2 O 2 depends on the formation of a disulfide bond between Cys 226 and 613, and this sensing mechanism differs from that used by electrophilic NRF2 inducers, suggesting the plausibility of cysteinylation of these two residues in cells [25]

10.1055/s-0043-119882 35 BraticA.LarssonN

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